Spyre Therapeutics

SYRENasdaq United States Health Care Biotechnology: Pharmaceutical Preparations

Market cap

$9.250 B

$104.91 +1.44%

Close of 7 Aug 2026

Revenue

$0.00

#3658 by revenue

Earnings

-$155.2M

Loss-making

Shares outstanding

88,173,762

Latest filing cover page

P/E ratio

—

Cap ÷ net income

Biotechnology: Pharmaceutical Preparations — ranked by market cap

All 501 →

#39Protagonist TherapeuticsPTGX$9.44B
#40Ionis PharmaceuticalsIONS$9.40B
#41Spyre TherapeuticsSYRE$9.25B
#42Crinetics PharmaceuticalsCRNX$8.92B
#43AlkermesALKS$8.25B

Where these numbers come from

Share counts and financials for Spyre Therapeutics are taken from its own SEC filings via EDGAR — public record, not an estimate. Market cap is shares outstanding multiplied by the latest close. Last updated 9 Aug 2026. Read the methodology.